HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.

Blog Article

The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity.This study presents a cross-sectional/longitudinal study of HIV-1 single nucleotide polymorphisms (SNPs) contained within the viral promoter or long terminal repeat (LTR) in patients within Antenna Balun the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort.HIV-1 LTR SNPs were found to associate with the classical clinical disease parameters CD4+ T-cell count and German Martingale log viral load.

They were found in both defined and undefined transcription factor binding sites of the LTR.A novel SNP identified at position 108 in a known COUP (chicken ovalbumin upstream promoter)/AP1 transcription factor binding site was significantly correlated with binding phenotypes that are potentially the underlying cause of the associated clinical outcome (increase in viral load and decrease in CD4+ T-cell count).